7crb

Cryo-EM structure of plant NLR RPP1 LRR-ID domain in complex with ATR1Cryo-EM structure of plant NLR RPP1 LRR-ID domain in complex with ATR1

Structural highlights

7crb is a 2 chain structure with sequence from Arabidopsis thaliana and Hyaloperonospora arabidopsidis Emoy2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.16Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ATR1_HYAAE Secreted effector that acts as an elicitor of hypersensitive response (HR) specifically on plants carrying both defense protein RPP1 from several ecotypes including RPP1-NdA, RPP1-WsB, RPP1-EstA and RPP1-ZdrA.^[1] ^[2] ^[3] ^[4] ^[5] ^[6]

References

↑ Rehmany AP, Gordon A, Rose LE, Allen RL, Armstrong MR, Whisson SC, Kamoun S, Tyler BM, Birch PR, Beynon JL. Differential recognition of highly divergent downy mildew avirulence gene alleles by RPP1 resistance genes from two Arabidopsis lines. Plant Cell. 2005 Jun;17(6):1839-50. PMID:15894715 doi:10.1105/tpc.105.031807
↑ Krasileva KV, Zheng C, Leonelli L, Goritschnig S, Dahlbeck D, Staskawicz BJ. Global analysis of Arabidopsis/downy mildew interactions reveals prevalence of incomplete resistance and rapid evolution of pathogen recognition. PLoS One. 2011;6(12):e28765. doi: 10.1371/journal.pone.0028765. Epub 2011 Dec 14. PMID:22194907 doi:http://dx.doi.org/10.1371/journal.pone.0028765
↑ Steinbrenner AD, Goritschnig S, Staskawicz BJ. Recognition and activation domains contribute to allele-specific responses of an Arabidopsis NLR receptor to an oomycete effector protein. PLoS Pathog. 2015 Feb 11;11(2):e1004665. PMID:25671309 doi:10.1371/journal.ppat.1004665
↑ Goritschnig S, Steinbrenner AD, Grunwald DJ, Staskawicz BJ. Structurally distinct Arabidopsis thaliana NLR immune receptors recognize tandem WY domains of an oomycete effector. New Phytol. 2016 May;210(3):984-96. PMID:26725254 doi:10.1111/nph.13823
↑ Schreiber KJ, Bentham A, Williams SJ, Kobe B, Staskawicz BJ. Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death. PLoS Pathog. 2016 Jul 18;12(7):e1005769. PMID:27427964 doi:10.1371/journal.ppat.1005769
↑ Atanasov KE, Liu C, Erban A, Kopka J, Parker JE, Alcázar R. NLR Mutations Suppressing Immune Hybrid Incompatibility and Their Effects on Disease Resistance. Plant Physiol. 2018 Jul;177(3):1152-1169. PMID:29794019 doi:10.1104/pp.18.00462

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OCA

[1] Rehmany AP, Gordon A, Rose LE, Allen RL, Armstrong MR, Whisson SC, Kamoun S, Tyler BM, Birch PR, Beynon JL. Differential recognition of highly divergent downy mildew avirulence gene alleles by RPP1 resistance genes from two Arabidopsis lines. Plant Cell. 2005 Jun;17(6):1839-50. PMID:15894715 doi:10.1105/tpc.105.031807

[2] Krasileva KV, Zheng C, Leonelli L, Goritschnig S, Dahlbeck D, Staskawicz BJ. Global analysis of Arabidopsis/downy mildew interactions reveals prevalence of incomplete resistance and rapid evolution of pathogen recognition. PLoS One. 2011;6(12):e28765. doi: 10.1371/journal.pone.0028765. Epub 2011 Dec 14. PMID:22194907 doi:http://dx.doi.org/10.1371/journal.pone.0028765

[3] Steinbrenner AD, Goritschnig S, Staskawicz BJ. Recognition and activation domains contribute to allele-specific responses of an Arabidopsis NLR receptor to an oomycete effector protein. PLoS Pathog. 2015 Feb 11;11(2):e1004665. PMID:25671309 doi:10.1371/journal.ppat.1004665

[4] Goritschnig S, Steinbrenner AD, Grunwald DJ, Staskawicz BJ. Structurally distinct Arabidopsis thaliana NLR immune receptors recognize tandem WY domains of an oomycete effector. New Phytol. 2016 May;210(3):984-96. PMID:26725254 doi:10.1111/nph.13823

[5] Schreiber KJ, Bentham A, Williams SJ, Kobe B, Staskawicz BJ. Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death. PLoS Pathog. 2016 Jul 18;12(7):e1005769. PMID:27427964 doi:10.1371/journal.ppat.1005769

[6] Atanasov KE, Liu C, Erban A, Kopka J, Parker JE, Alcázar R. NLR Mutations Suppressing Immune Hybrid Incompatibility and Their Effects on Disease Resistance. Plant Physiol. 2018 Jul;177(3):1152-1169. PMID:29794019 doi:10.1104/pp.18.00462

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