6jma

cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosomecryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome

6jma, resolution 6.80Å Show:Asymmetric Unit Biological Assembly Structural highlights 6jma is a 12 chain structure with sequence from Homo sapiens, Xenopus laevis and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 6.8Å Ligands: Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function H32_XENLA Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. See Also Histone 3D structures Histone methyltransferase 3D structures