8too

Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12

Structural highlights

8too is a 12 chain structure with sequence from Human gammaherpesvirus 4 and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.6Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GP42_EBVB9 Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells.^[1]

References

↑ Borza CM, Hutt-Fletcher LM. Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nat Med. 2002 Jun;8(6):594-9. PMID:12042810 doi:10.1038/nm0602-594

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OCA

[1] Borza CM, Hutt-Fletcher LM. Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nat Med. 2002 Jun;8(6):594-9. PMID:12042810 doi:10.1038/nm0602-594

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8too

Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12

Structural highlights

Function

References

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8too

Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12

Structural highlights

Function

References

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