1e5w

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Structure of isolated FERM domain and first long helix of moesinStructure of isolated FERM domain and first long helix of moesin

Structural highlights

1e5w is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MOES_HUMAN Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Henning MS, Stiedl P, Barry DS, McMahon R, Morham SG, Walsh D, Naghavi MH. PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1. Virology. 2011 Jul 5;415(2):114-21. doi: 10.1016/j.virol.2011.04.006. Epub 2011, May 6. PMID:21549406 doi:10.1016/j.virol.2011.04.006

1e5w, resolution 2.70Å

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