N-terminal RING finger domain of human NOT-4N-terminal RING finger domain of human NOT-4
Structural highlights
1e4u is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
CNOT4_HUMAN Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT. Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex. EMBO J. 2002 Feb 1;21(3):355-64. PMID:11823428 doi:http://dx.doi.org/10.1093/emboj/21.3.355
