3rg9

Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210

Structural highlights 3rg9 is a 2 chain structure with sequence from Trypanosoma brucei rhodesiense. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DRTS_TRYBB Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity). See Also Dihydrofolate reductase 3D structures

spinqualitylabelsall models 3rg9, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image