4gr0

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470BCrystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B

Structural highlights 4gr0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.497Å Ligands: , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MMP12_HUMAN May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. See Also Matrix metalloproteinase 3D structures

spinqualitylabelsall models 4gr0, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image