4dws

Crystal Structure of a chitinase from the Yersinia entomophaga toxin complexCrystal Structure of a chitinase from the Yersinia entomophaga toxin complex

Structural highlights

4dws is a 4 chain structure with sequence from Yersinia entomophaga. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHI2_YERET Part of an orally active toxin complex (TC) with strong insecticidal effects on larvae of the Coleoptera Costelytra zealandica, Acrossidius tasmania and Adoryphorus couloni and some Lepidoptera larvae (PubMed:21278295). The TC has an endochitinase activity (PubMed:21278295, PubMed:22158901) (Probable). This subunit might aid infection by degradation of the larval peritrophic membrane (Probable).^[1] ^[2] ^[3]

References

↑ Hurst MR, Jones SA, Binglin T, Harper LA, Jackson TA, Glare TR. The main virulence determinant of Yersinia entomophaga MH96 is a broad-host-range toxin complex active against insects. J Bacteriol. 2011 Apr;193(8):1966-80. doi: 10.1128/JB.01044-10. Epub 2011 Jan 28. PMID:21278295 doi:http://dx.doi.org/10.1128/JB.01044-10
↑ Landsberg MJ, Jones SA, Rothnagel R, Busby JN, Marshall SD, Simpson RM, Lott JS, Hankamer B, Hurst MR. 3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20544-9. doi:, 10.1073/pnas.1111155108. Epub 2011 Dec 7. PMID:22158901 doi:http://dx.doi.org/10.1073/pnas.1111155108
↑ Busby JN, Landsberg MJ, Simpson R, Jones SA, Hankamer B, Hurst MR, Lott JS. Structural Analysis of Chi1 Chitinase from Yen-Tc: The Multisubunit Insecticidal ABC Toxin Complex of Yersinia entomophaga. J Mol Biol. 2011 Nov 15. PMID:22108167 doi:10.1016/j.jmb.2011.11.018

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OCA

[1] Hurst MR, Jones SA, Binglin T, Harper LA, Jackson TA, Glare TR. The main virulence determinant of Yersinia entomophaga MH96 is a broad-host-range toxin complex active against insects. J Bacteriol. 2011 Apr;193(8):1966-80. doi: 10.1128/JB.01044-10. Epub 2011 Jan 28. PMID:21278295 doi:http://dx.doi.org/10.1128/JB.01044-10

[2] Landsberg MJ, Jones SA, Rothnagel R, Busby JN, Marshall SD, Simpson RM, Lott JS, Hankamer B, Hurst MR. 3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20544-9. doi:, 10.1073/pnas.1111155108. Epub 2011 Dec 7. PMID:22158901 doi:http://dx.doi.org/10.1073/pnas.1111155108

[3] Busby JN, Landsberg MJ, Simpson R, Jones SA, Hankamer B, Hurst MR, Lott JS. Structural Analysis of Chi1 Chitinase from Yen-Tc: The Multisubunit Insecticidal ABC Toxin Complex of Yersinia entomophaga. J Mol Biol. 2011 Nov 15. PMID:22108167 doi:10.1016/j.jmb.2011.11.018

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