6cvf

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphateCrystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphate

Structural highlights

6cvf is a 4 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.3Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BIOD_MYCTU Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.^[1]

References

↑ Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10;49(31):6746-60. PMID:20565114 doi:10.1021/bi902097j

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OCA

[1] Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10;49(31):6746-60. PMID:20565114 doi:10.1021/bi902097j

[1]

6cvf

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphateCrystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphate

Structural highlights

Function

See Also

References

Contents

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