6bp8

Recombinant major vault protein [Rattus norvegicus] structure in solution: conformation 1Recombinant major vault protein [Rattus norvegicus] structure in solution: conformation 1

6bp8, resolution 4.90Å Show:Asymmetric Unit Biological Assembly Structural highlights 6bp8 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.9Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MVP_RAT Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).