1ssl
Solution structure of the PSI domain from the Met receptor
|
OverviewOverview
PSI domains are cysteine-rich modules found in extracellular fragments of, hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain, from the human Met receptor, a receptor tyrosine kinase critical for, proliferation, motility, and differentiation. The structure represents a, cysteine knot with short regions of secondary structure including a, three-stranded antiparallel beta-sheet and two alpha-helices. All eight, cysteines are involved in disulfide bonds with the pattern consistent with, that for the PSI domain from Sema4D. Comparison with the Sema4D structure, identifies a structurally conserved core comprising the N-terminal half of, the PSI domain. Interestingly, this part links adjacent SEMA and, immunoglobulin domains in the Sema4D structure, suggesting that the PSI, domain serves as a wedge between propeller and immunoglobulin domains and, is responsible for the correct positioning of the ligand-binding site of, the receptor.
DiseaseDisease
Known diseases associated with this structure: Autism, suseptibility to, 9 OMIM:[164860], Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860]
About this StructureAbout this Structure
1SSL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Insights into function of PSI domains from structure of the Met receptor PSI domain., Kozlov G, Perreault A, Schrag JD, Park M, Cygler M, Gehring K, Ekiel I, Biochem Biophys Res Commun. 2004 Aug 13;321(1):234-40. PMID:15358240
Page seeded by OCA on Mon Nov 12 19:17:21 2007