4m2x

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Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)

Structural highlights

4m2x is a 4 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.26Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_MYCTU Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

See Also

4m2x, resolution 2.26Å

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OCA
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