4jdx

Structure of the Fluorescence Recovery Protein from Synechocystis sp PCC 6803Structure of the Fluorescence Recovery Protein from Synechocystis sp PCC 6803

Structural highlights

4jdx is a 6 chain structure with sequence from Synechocystis sp. PCC 6803 substr. Kazusa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FRP_SYNY3 Destabilizes orange carotenoid protein-R form (OCP-R), the FRP-OCP interaction accelerates the OCP-R to OCP-O conversion (PubMed:20534537, PubMed:23716688). Increases fluorescence recovery following non-photochemical quenching (NPQ) by OCP, most probably by destabilizing OCP-R binding to the phycobilisome core (PubMed:21764991).^[1] ^[2] ^[3]

References

↑ Boulay C, Wilson A, D'Haene S, Kirilovsky D. Identification of a protein required for recovery of full antenna capacity in OCP-related photoprotective mechanism in cyanobacteria. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11620-5. doi: , 10.1073/pnas.1002912107. Epub 2010 Jun 7. PMID:20534537 doi:http://dx.doi.org/10.1073/pnas.1002912107
↑ Gwizdala M, Wilson A, Kirilovsky D. In vitro reconstitution of the cyanobacterial photoprotective mechanism mediated by the Orange Carotenoid Protein in Synechocystis PCC 6803. Plant Cell. 2011 Jul;23(7):2631-43. doi: 10.1105/tpc.111.086884. Epub 2011 Jul , 15. PMID:21764991 doi:http://dx.doi.org/10.1105/tpc.111.086884
↑ Sutter M, Wilson A, Leverenz RL, Lopez-Igual R, Thurotte A, Salmeen AE, Kirilovsky D, Kerfeld CA. Crystal structure of the FRP and identification of the active site for modulation of OCP-mediated photoprotection in cyanobacteria. Proc Natl Acad Sci U S A. 2013 May 28. PMID:23716688 doi:10.1073/pnas.1303673110

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OCA

[1] Boulay C, Wilson A, D'Haene S, Kirilovsky D. Identification of a protein required for recovery of full antenna capacity in OCP-related photoprotective mechanism in cyanobacteria. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11620-5. doi: , 10.1073/pnas.1002912107. Epub 2010 Jun 7. PMID:20534537 doi:http://dx.doi.org/10.1073/pnas.1002912107

[2] Gwizdala M, Wilson A, Kirilovsky D. In vitro reconstitution of the cyanobacterial photoprotective mechanism mediated by the Orange Carotenoid Protein in Synechocystis PCC 6803. Plant Cell. 2011 Jul;23(7):2631-43. doi: 10.1105/tpc.111.086884. Epub 2011 Jul , 15. PMID:21764991 doi:http://dx.doi.org/10.1105/tpc.111.086884

[3] Sutter M, Wilson A, Leverenz RL, Lopez-Igual R, Thurotte A, Salmeen AE, Kirilovsky D, Kerfeld CA. Crystal structure of the FRP and identification of the active site for modulation of OCP-mediated photoprotection in cyanobacteria. Proc Natl Acad Sci U S A. 2013 May 28. PMID:23716688 doi:10.1073/pnas.1303673110

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