3ont

The Crystal Structure of Spot14, a modulator of lipogenesisThe Crystal Structure of Spot14, a modulator of lipogenesis

Structural highlights

3ont is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.65Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THRSP_MOUSE Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity).^[1] ^[2]

References

↑ Zhu Q, Anderson GW, Mucha GT, Parks EJ, Metkowski JK, Mariash CN. The Spot 14 protein is required for de novo lipid synthesis in the lactating mammary gland. Endocrinology. 2005 Aug;146(8):3343-50. Epub 2005 May 12. PMID:15890771 doi:10.1210/en.2005-0204
↑ Colbert CL, Kim CW, Moon YA, Henry L, Palnitkar M, McKean WB, Fitzgerald K, Deisenhofer J, Horton JD, Kwon HJ. Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18820-5. Epub 2010 Oct 15. PMID:20952656 doi:10.1073/pnas.1012736107

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OCA

[1] Zhu Q, Anderson GW, Mucha GT, Parks EJ, Metkowski JK, Mariash CN. The Spot 14 protein is required for de novo lipid synthesis in the lactating mammary gland. Endocrinology. 2005 Aug;146(8):3343-50. Epub 2005 May 12. PMID:15890771 doi:10.1210/en.2005-0204

[2] Colbert CL, Kim CW, Moon YA, Henry L, Palnitkar M, McKean WB, Fitzgerald K, Deisenhofer J, Horton JD, Kwon HJ. Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18820-5. Epub 2010 Oct 15. PMID:20952656 doi:10.1073/pnas.1012736107

[1]

[2]

3ont

The Crystal Structure of Spot14, a modulator of lipogenesisThe Crystal Structure of Spot14, a modulator of lipogenesis

Structural highlights

Function

References

Contents

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3ont

The Crystal Structure of Spot14, a modulator of lipogenesisThe Crystal Structure of Spot14, a modulator of lipogenesis

Structural highlights

Function

References

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