3ia4

Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)

Structural highlights 3ia4 is a 4 chain structure with sequence from Moritella profunda. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q70YQ6_MORPR Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Dihydrofolate reductase 3D structures

spinqualitylabelsall models 3ia4, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image