3fy4

(6-4) Photolyase Crystal Structure(6-4) Photolyase Crystal Structure

Structural highlights

3fy4 is a 3 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UVR3_ARATH Involved in repair of UV radiation-induced DNA damage. Catalyzes the photoreactivation of pyrimidine [6-4] pyrimidone photoproduct (6-4 products). Binds specifically to DNA containing 6-4 products and repairs these lesions in a visible light-dependent manner. Not required for repair of cyclobutane pyrimidine dimer (CPD).^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Schleicher E, Hitomi K, Kay CW, Getzoff ED, Todo T, Weber S. Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase. J Biol Chem. 2007 Feb 16;282(7):4738-47. Epub 2006 Dec 12. PMID:17164245 doi:http://dx.doi.org/10.1074/jbc.M604734200
↑ Nakajima S, Sugiyama M, Iwai S, Hitomi K, Otoshi E, Kim ST, Jiang CZ, Todo T, Britt AB, Yamamoto K. Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana. Nucleic Acids Res. 1998 Jan 15;26(2):638-44. PMID:9421527

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OCA

[1] Schleicher E, Hitomi K, Kay CW, Getzoff ED, Todo T, Weber S. Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase. J Biol Chem. 2007 Feb 16;282(7):4738-47. Epub 2006 Dec 12. PMID:17164245 doi:http://dx.doi.org/10.1074/jbc.M604734200

[2] Nakajima S, Sugiyama M, Iwai S, Hitomi K, Otoshi E, Kim ST, Jiang CZ, Todo T, Britt AB, Yamamoto K. Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana. Nucleic Acids Res. 1998 Jan 15;26(2):638-44. PMID:9421527

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