7akq

Structure of D169A/E171A double mutant of chitinase Chit42 from Trichoderma harzianum complexed with chitintetraose obtained by soaking.Structure of D169A/E171A double mutant of chitinase Chit42 from Trichoderma harzianum complexed with chitintetraose obtained by soaking.

Structural highlights

7akq is a 1 chain structure with sequence from Trichoderma harzianum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.32Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHI42_TRIHA Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a morphogenetic role during apical growth, cell division and differentiation (cell wall morphogenesis). Acts also as an antifungal agent. Involved in the degradation and further assimilation of phytopathogenic fungi, namely mycoparasitism, the major mechanism accounting for the antagonistic activity against phytopathogenic fungi displayed by Trichoderma.^[1]

References

↑ de la Cruz J, Hidalgo-Gallego A, Lora JM, Benitez T, Pintor-Toro JA, Llobell A. Isolation and characterization of three chitinases from Trichoderma harzianum. Eur J Biochem. 1992 Jun 15;206(3):859-67. PMID:1606968

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OCA

[1] Cruz J, Hidalgo-Gallego A, Lora JM, Benitez T, Pintor-Toro JA, Llobell A. Isolation and characterization of three chitinases from Trichoderma harzianum. Eur J Biochem. 1992 Jun 15;206(3):859-67. PMID:1606968

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