8c7d

Structure of the GEF Kalirin DH2 DomainStructure of the GEF Kalirin DH2 Domain

Structural highlights

8c7d is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.86Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

KALRN_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

KALRN_HUMAN Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.^[1]

References

↑ Kawai T, Sanjo H, Akira S. Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene. 1999 Feb 18;227(2):249-55. doi: 10.1016/s0378-1119(98)00605-2. PMID:10023074 doi:http://dx.doi.org/10.1016/s0378-1119(98)00605-2

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OCA

[1] Kawai T, Sanjo H, Akira S. Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene. 1999 Feb 18;227(2):249-55. doi: 10.1016/s0378-1119(98)00605-2. PMID:10023074 doi:http://dx.doi.org/10.1016/s0378-1119(98)00605-2

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