1iyg

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Solution structure of RSGI RUH-001, a Fis1p-like and CGI-135 homologous domain from a mouse cDNASolution structure of RSGI RUH-001, a Fis1p-like and CGI-135 homologous domain from a mouse cDNA

Structural highlights

1iyg is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

FIS1_MOUSE Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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