7dfc

Crystal of Arrestin2-V2Rpp-3-Fab30 complexCrystal of Arrestin2-V2Rpp-3-Fab30 complex

Structural highlights

7dfc is a 4 chain structure with sequence from Bos taurus, Mus musculus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.49Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

V2R_HUMAN Nephrogenic syndrome of inappropriate antidiuresis;Inappropriate antidiuretic hormone secretion syndrome;Nephrogenic diabetes insipidus. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

V2R_HUMAN Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.^[1]

References

↑ Boselt I, Rompler H, Hermsdorf T, Thor D, Busch W, Schulz A, Schoneberg T. Involvement of the V2 vasopressin receptor in adaptation to limited water supply. PLoS One. 2009;4(5):e5573. doi: 10.1371/journal.pone.0005573. Epub 2009 May 18. PMID:19440390 doi:http://dx.doi.org/10.1371/journal.pone.0005573

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OCA

[1] Boselt I, Rompler H, Hermsdorf T, Thor D, Busch W, Schulz A, Schoneberg T. Involvement of the V2 vasopressin receptor in adaptation to limited water supply. PLoS One. 2009;4(5):e5573. doi: 10.1371/journal.pone.0005573. Epub 2009 May 18. PMID:19440390 doi:http://dx.doi.org/10.1371/journal.pone.0005573

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