6jrl

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Crystal structure of Drosophila alpha methyldopa-resistant protein/3,4-dihydroxyphenylacetaldehyde synthaseCrystal structure of Drosophila alpha methyldopa-resistant protein/3,4-dihydroxyphenylacetaldehyde synthase

Structural highlights

6jrl is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DHAPP_DROME Catalyzes both the decarboxylation and deamination of L-dopa to 3,4-dihydroxylphenylacetaldehyde (DHPAA) (PubMed:21283636). Probably responsible for the protein cross-linking during the development of flexible cuticles (PubMed:21283636). Participates in catecholamine catabolism (PubMed:21283636).[1]

References

  1. ↑ Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J. From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects. PLoS One. 2011 Jan 24;6(1):e16124. doi: 10.1371/journal.pone.0016124. PMID:21283636 doi:http://dx.doi.org/10.1371/journal.pone.0016124

6jrl, resolution 2.20Å

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