Signal recognition particle receptor

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Signal recognition particle receptor (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the signal recognition particle (SRP). SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called FtsY.

See also Intracellular receptors

  • . Water molecules are shown as red spheres.
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3D structures of signal recognition particle receptor

Signal recognition particle receptor 3D structures


Human SRPR α (magenta) and β subunit (deepskyblue) complex with GTP and Mg+2 (green) ion 2fh5

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Michal Harel, Alexander Berchansky, Joel L. Sussman