1oll
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EXTRACELLULAR REGION OF THE HUMAN RECEPTOR NKP46
OverviewOverview
NKp46, a natural killer (NK) cell-specific receptor, has been recently, identified as one of the triggering receptors involved in NK cell, activation mediated by non-HLA class I ligands. The structure of the NKp46, extracellular receptor region, here reported, consists of two Ig-like, domains assembled similarly to leukocyte immunoglobulin-like receptors, (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue, substitutions at sites structurally related to those mediating interaction, with HLA antigens in LIRs and KIRs indicate that NKp46 recognition, processes in vivo should involve non-HLA ligands. NKP46 is shown to stem, from an ancestral KIR/LIR family. However, the absence of close, paralogues, such as those found for LIR and KIR, indicates that NKp46 is, the unique member of a distinct Ig-like subfamily and suggests a specific, role, which appears to be maintained across primates and rodents.
About this StructureAbout this Structure
1OLL is a Single protein structure of sequence from Escherichia coli with EDO as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the human NK cell triggering receptor NKp46 ectodomain., Ponassi M, Cantoni C, Biassoni R, Conte R, Spallarossa A, Pesce A, Moretta A, Moretta L, Bolognesi M, Bordo D, Biochem Biophys Res Commun. 2003 Sep 19;309(2):317-23. PMID:12951052
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