7uln

Turnip yellows virus N-terminal readthrough domainTurnip yellows virus N-terminal readthrough domain

Structural highlights

7uln is a 2 chain structure with sequence from Turnip yellows virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.53Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MCAPS_TYYVF Minor component of the viral capsid involved in aphid transmission and virus accumulation in the host (PubMed:7882968, PubMed:20416918, PubMed:26402374, PubMed:10627524). Required for the virus to move through the aphid (By similarity). The RTD domain of the protein is exposed on the surface of the particle and determines the vector specificity and intestinal tropism in the aphid (PubMed:7882968).[UniProtKB:P09516]^[1] ^[2] ^[3] ^[4]

References

↑ Brault V, Mutterer J, Scheidecker D, Simonis MT, Herrbach E, Richards K, Ziegler-Graff V. Effects of point mutations in the readthrough domain of the beet western yellows virus minor capsid protein on virus accumulation in planta and on transmission by aphids. J Virol. 2000 Feb;74(3):1140-8. doi: 10.1128/jvi.74.3.1140-1148.2000. PMID:10627524 doi:http://dx.doi.org/10.1128/jvi.74.3.1140-1148.2000
↑ Revollon S, Strub JM, Fitchette AC, Wiss L, Gomord V, Van Dorsselaer A, Brault V. A reinvestigation provides no evidence for sugar residues on structural proteins of poleroviruses and argues against a role for glycosylation of virus structural proteins in aphid transmission. Virology. 2010 Jul 5;402(2):303-14. doi: 10.1016/j.virol.2010.03.037. Epub 2010, Apr 22. PMID:20416918 doi:http://dx.doi.org/10.1016/j.virol.2010.03.037
↑ Rodriguez-Medina C, Boissinot S, Chapuis S, Gereige D, Rastegar M, Erdinger M, Revers F, Ziegler-Graff V, Brault V. A protein kinase binds the C-terminal domain of the readthrough protein of Turnip yellows virus and regulates virus accumulation. Virology. 2015 Dec;486:44-53. doi: 10.1016/j.virol.2015.08.031. Epub 2015 Sep 21. PMID:26402374 doi:http://dx.doi.org/10.1016/j.virol.2015.08.031
↑ Brault V, van den Heuvel JF, Verbeek M, Ziegler-Graff V, Reutenauer A, Herrbach E, Garaud JC, Guilley H, Richards K, Jonard G. Aphid transmission of beet western yellows luteovirus requires the minor capsid read-through protein P74. EMBO J. 1995 Feb 15;14(4):650-9. doi: 10.1002/j.1460-2075.1995.tb07043.x. PMID:7882968 doi:http://dx.doi.org/10.1002/j.1460-2075.1995.tb07043.x

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OCA

[1] Brault V, Mutterer J, Scheidecker D, Simonis MT, Herrbach E, Richards K, Ziegler-Graff V. Effects of point mutations in the readthrough domain of the beet western yellows virus minor capsid protein on virus accumulation in planta and on transmission by aphids. J Virol. 2000 Feb;74(3):1140-8. doi: 10.1128/jvi.74.3.1140-1148.2000. PMID:10627524 doi:http://dx.doi.org/10.1128/jvi.74.3.1140-1148.2000

[2] Revollon S, Strub JM, Fitchette AC, Wiss L, Gomord V, Van Dorsselaer A, Brault V. A reinvestigation provides no evidence for sugar residues on structural proteins of poleroviruses and argues against a role for glycosylation of virus structural proteins in aphid transmission. Virology. 2010 Jul 5;402(2):303-14. doi: 10.1016/j.virol.2010.03.037. Epub 2010, Apr 22. PMID:20416918 doi:http://dx.doi.org/10.1016/j.virol.2010.03.037

[3] Rodriguez-Medina C, Boissinot S, Chapuis S, Gereige D, Rastegar M, Erdinger M, Revers F, Ziegler-Graff V, Brault V. A protein kinase binds the C-terminal domain of the readthrough protein of Turnip yellows virus and regulates virus accumulation. Virology. 2015 Dec;486:44-53. doi: 10.1016/j.virol.2015.08.031. Epub 2015 Sep 21. PMID:26402374 doi:http://dx.doi.org/10.1016/j.virol.2015.08.031

[4] Brault V, van den Heuvel JF, Verbeek M, Ziegler-Graff V, Reutenauer A, Herrbach E, Garaud JC, Guilley H, Richards K, Jonard G. Aphid transmission of beet western yellows luteovirus requires the minor capsid read-through protein P74. EMBO J. 1995 Feb 15;14(4):650-9. doi: 10.1002/j.1460-2075.1995.tb07043.x. PMID:7882968 doi:http://dx.doi.org/10.1002/j.1460-2075.1995.tb07043.x

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