Ragulator complex

The ragulator complex (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it^[1].

3D structures of ragulator complex

Ragulator complex 3D structures

References

↑ Mu Z, Wang L, Deng W, Wang J, Wu G. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane. Cell Discov. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49. eCollection, 2017. PMID:29285400 doi:http://dx.doi.org/10.1038/celldisc.2017.49

Human ragulator complex proteins: LAMTOR1 coiled coil domain (grey and cyan) + LAMTOR2 roadblock domain (green and red) + LAMTOR3 roadblock domain (pink and gold) + LAMTOR4 roadblock domain (yellow and wheat) + LAMTOR5 roadblock domain (magenta and blue) PDB code 5y39

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Michal Harel, Wayne Decatur

[1] Mu Z, Wang L, Deng W, Wang J, Wu G. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane. Cell Discov. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49. eCollection, 2017. PMID:29285400 doi:http://dx.doi.org/10.1038/celldisc.2017.49

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