8ja8

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Crystal structure of Mycobacterium tuberculosis LpqY with trehalose bound in a closed liganded formCrystal structure of Mycobacterium tuberculosis LpqY with trehalose bound in a closed liganded form

Structural highlights

8ja8 is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LPQY_MYCTU Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence.[1]

References

  1. ↑ Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi:, 10.1073/pnas.1014642108. Epub 2010 Nov 30. PMID:21118978 doi:http://dx.doi.org/10.1073/pnas.1014642108

8ja8, resolution 1.60Å

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