4pzu

Crystal structure of a putative uncharacterize protein Rv3404c and likely sugar N-formyltransferase from Mycobacterium tuberculosisCrystal structure of a putative uncharacterize protein Rv3404c and likely sugar N-formyltransferase from Mycobacterium tuberculosis

Structural highlights

4pzu is a 8 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SUGFT_MYCTU Sugar N-formyltransferase that catalyzes the conversion of dTDP-4-amino-4,6-dideoxyglucose into dTDP-4-formamido-4,6-dideoxyglucose using N(10)-formyltetrahydrofolate as the carbon source (PubMed:28665588). Plays a role in virulence (PubMed:12368431). Has no activity on dTDP-3-amino-3,6-dideoxyglucose, dTDP-3-amino-3,6-dideoxygalactose, UDP-4-amino-4-deoxyarabinose, and GDP-4-amino-4,6-dideoxymannose (PubMed:28665588).^[1] ^[2]

References

↑ McAdam RA, Quan S, Smith DA, Bardarov S, Betts JC, Cook FC, Hooker EU, Lewis AP, Woollard P, Everett MJ, Lukey PT, Bancroft GJ, Jacobs WR Jr, Duncan K. Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence. Microbiology (Reading). 2002 Oct;148(Pt 10):2975-2986. PMID:12368431 doi:10.1099/00221287-148-10-2975
↑ Dunsirn MM, Thoden JB, Gilbert M, Holden HM. Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis. Biochemistry. 2017 Jul 25;56(29):3818-3825. doi: 10.1021/acs.biochem.7b00506., Epub 2017 Jul 14. PMID:28665588 doi:http://dx.doi.org/10.1021/acs.biochem.7b00506

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OCA

[1] McAdam RA, Quan S, Smith DA, Bardarov S, Betts JC, Cook FC, Hooker EU, Lewis AP, Woollard P, Everett MJ, Lukey PT, Bancroft GJ, Jacobs WR Jr, Duncan K. Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence. Microbiology (Reading). 2002 Oct;148(Pt 10):2975-2986. PMID:12368431 doi:10.1099/00221287-148-10-2975

[2] Dunsirn MM, Thoden JB, Gilbert M, Holden HM. Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis. Biochemistry. 2017 Jul 25;56(29):3818-3825. doi: 10.1021/acs.biochem.7b00506., Epub 2017 Jul 14. PMID:28665588 doi:http://dx.doi.org/10.1021/acs.biochem.7b00506

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