1n7d
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Extracellular domain of the LDL receptor
OverviewOverview
The low-density lipoprotein receptor mediates cholesterol homeostasis, through endocytosis of lipoproteins. It discharges its ligand in the, endosome at pH < 6. In the crystal structure at pH = 5.3, the, ligand-binding domain (modules R2 to R7) folds back as an arc over the, epidermal growth factor precursor homology domain (the modules A, B, beta, propeller, and C). The modules R4 and R5, which are critical for, lipoprotein binding, associate with the beta propeller via their, calcium-binding loop. We propose a mechanism for lipoprotein release in, the endosome whereby the beta propeller functions as an alternate, substrate for the ligand-binding domain, binding in a calcium-dependent, way and promoting lipoprotein release.
DiseaseDisease
Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]
About this StructureAbout this Structure
1N7D is a Single protein structure of sequence from Homo sapiens with CA and KEG as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the LDL receptor extracellular domain at endosomal pH., Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J, Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29. PMID:12459547
Page seeded by OCA on Mon Nov 12 18:18:41 2007