Prostaglandin E synthase

Function Microsomal Prostaglandin E synthase (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2 . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory glucocorticoids. See also: Glucocorticoids; Steroid Hormones and their receptors.. Relevance PGES participates in several pathophysiological states in which COX-2 is involved and hence represents a potential target for anti-inflammatory and anti-cancer drug development . Structural highlights Microsomal Prostaglandin E synthase (coordinates are from OPM database. The . Water molecules are shown as red spheres.

spinqualitylabelsall models Human PGES complex with inhibitor and glutathione (PDB code 4yl0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of prostaglandin E synthase3D Structures of prostaglandin E synthase

Updated on 13-September-2023

3dww, 4al0, 4wab, 4bpm – hPGES-1 + glutathione – human
4al1 – hPGES-1 + glutathione analog
6vl4 – hPGES-1 + inhibitor
5bqg, 5bqh, 5bqi, 5k0i, 5t36, 5t37, 5tl9, 4yk5, 4yl0, 4yl1, 4yl3 – hPGES-1 + glutathione + inhibitor
7l7j – hPGES-3 + Hsp90 – Cryo EM
7l7i – hPGES-3 + Hsp90 + FKBP5 – Cryo EM
7krj – hPGES-3 + Hsp90 + glucocorticoid receptor – Cryo EM
1z9h – MaPGES-2 + indomethacin – Macaque
2pbj – MaPGES-2 + heme + glutathione
7y04 – mPGES-3 + Hsp90 + AHR - mouse – Cryo EM
8h77 – mPGES-3 + Hsp90 + AHR + AHR-interacting protein – Cryo EM