1fgb

OverviewOverview

Cholera toxin, a heterohexameric AB5 enterotoxin released by Vibrio, cholera, induces a profuse secretory diarrhea in susceptible hosts., Choleragenoid, the B subunit pentamer of cholera toxin, directs the, enzymatic A subunit to its target by binding the GM1 gangliosides exposed, on the luminal surface of intestinal epithelial cells. The crystal, structure of choleragenoid has been independently solved and refined at, 2.4 A resolution by combining single isomorphous replacement with, non-crystallographic symmetry averaging. The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the, intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia, coli, and for a choleragenoid-GM1 pentasaccharide complex. In the absence, of the A ... [(full description)]

About this StructureAbout this Structure

1FGB is a [Single protein] structure of sequence from [Vibrio cholerae]. Full crystallographic information is available from [OCA].

ReferenceReference

The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid., Zhang RG, Westbrook ML, Westbrook EM, Scott DL, Otwinowski Z, Maulik PR, Reed RA, Shipley GG, J Mol Biol. 1995 Aug 25;251(4):550-62. PMID:7658472

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