Crystal Structure of E. coli OligoribonucleaseCrystal Structure of E. coli Oligoribonuclease
Structural highlights
2igi is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
ORN_ECOLI 3'-to-5' exoribonuclease specific for small oligoribonucleotides 2 to 5 nucleotides in length, as well as small (2 to 5 nucleotides) ssDNA oligomers. Probably responsible for the final step in mRNA degradation.[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Zhang X, Zhu L, Deutscher MP. Oligoribonuclease is encoded by a highly conserved gene in the 3'-5' exonuclease superfamily. J Bacteriol. 1998 May;180(10):2779-81. PMID:9573169
↑Yu D, Deutscher MP. Oligoribonuclease is distinct from the other known exoribonucleases of Escherichia coli. J Bacteriol. 1995 Jul;177(14):4137-9. PMID:7608090
↑Mechold U, Ogryzko V, Ngo S, Danchin A. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. Nucleic Acids Res. 2006 May 8;34(8):2364-73. Print 2006. PMID:16682444 doi:http://dx.doi.org/10.1093/nar/gkl247
