Pantothenate synthetase

Function Pantothenate synthetase or pantoate-beta-alanine ligase (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. Relevance Pantothenate (vitamin B5) biosynthesis is essential for the virulence of Mycobacterium tuberculosis thus its blockage can be used as a potential drug target. Structural highlights PS . In this structure the pantoate substrate electron density is well defined in one subunit while the nucleotide electron density is well defined in the other. Water molecules are shown as red spheres. (chain A). (chain B).

spinqualitylabelsall models Pantothenate synthetase complex with pantoate, AMPPNP, sulfate, Mg+2 ion (green), ethanol and glycerol (PDB entry 1n2e) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of pantothenate synthetase3D structures of pantothenate synthetase

Updated on 21-August-2023

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• Pantothenate synthetase
  • 1iho – EcPS – Escherichia coli
    
  • 1mop, 2a88, 3cov – MtPS (mutant) – Mycobacterium tuberculosis
    
  • 1ufv - TtPS (mutant) – Thermus thermophilus
    
  • 1v8f - TtPS
    
  • 2ejc - PS – Thermotoga maritima
    
  • 3mue - PS – Salmonella typhimurium
    
  • 3mxt - CjPS – Campylobacter jejuni
    
  • 3ag5 - SaPS – Staphylococcus aureus
    
  • 5hg0 - FtPS + SAM – Francisella tularensis
    
  • 7tot - PS – Bartonella henselae
    
• Pantothenate synthetase binary complex with adenosine derivatives
  • 1n2g - MtPS + AMPCPP
    
  • 2a7x - MtPS (mutant) + AMP
    
  • 3n8h - FtPS + AMP
    
  • 3q10 - YpPS + AMP – Yersinia pestis
    
  • 3uk2 - PS + AMP – Burkholderia thailandesis
    
  • 2a84 - MtPS (mutant) + ATP
    
  • 2x3f - SaPS + ATP derivative
    
  • 3inn - PS + ATP – Brucella melitensis
    
  • 3iob, 3ioc, 3iod, 3ioe - MtPS (mutant) + adenosine derivative
    
  • 5kwv – NgPS (mutant) + AMPPNP – Neisseria gonorrhoeae
    
• Pantothenate synthetase binary complex with pantoate derivatives
  • 1n2i, 1n2h - MtPS (mutant) + pantoyl adenylate
    
  • 1n2j - MtPS (mutant) + pantoate
    
  • 1n2o - MtPS (mutant) + β-alanine
    
  • 3q12 - YpPS + pantoate
    
  • 3ag6 - SaPS + pantoyl adenylate
    
  • 3guz - EcPS (mutant) + pantoate
• Pantothenate synthetase binary complex with inhibitor
  • 3cow, 3coy, 3coz, 3imc, 3ime, 3img, 3iub, 3iue, 3ivc, 3ivg, 3ivx, 3isj, 3le8, 4ddh, 4ddk, 4ddm, 4de5, 4ef6, 4efk, 4fzj, 4g5f, 4mq6, 4mue, 4muf, 4mug, 4muh, 4mui, 4muj, 4muk, 4mul, 4mun - MtPS (mutant) + inhibitor
• Pantothenate synthetase ternary complex
  • 2a86 - MtPS (mutant) + β-alanine + AMP
    
  • 5ucr – NgPS (mutant) + AMP + alanine
    
  • 4g5y - MtPS (mutant) + thiophene derivative + ATP
    
  • 3uy4 - CjPS + pantothenate + AMP
    
  • 3qtt - FtPS + β-alanine + ATP derivative
    
  • 1n2b, 1n2e – MtPS + pantoate + AMPCPP