Neuroglobin

Function

Neuroglobin (NGB) is involved in cellular oxygen homeostasis. It binds oxygen reversibly. It increases oxygen availability in the brain. It is a monomer containing a heme group^[1].

Relevance

NGB may influence the course of Alzhheimer's disease^[2].

Structural highlights

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Mouse neuroglobin showing the heme and complexed with sulfate and Xe 3gk9

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3D Structures of Neuroglobin3D Structures of Neuroglobin

Updated on 13-July-2023

4mpm – hNGB - human
1oj6, 7vqg – hNGB (mutant)
5eet, 6r1q – mNGB – mouse
3gk9, 3gkt, 2vry, 1q1f, 4mu5, 4nzi, 4o1t, 4o4t, 5eoh, 5eqm, 5eu2, 5ev5, 5eyj, 5eys, 5f0b, 5f2a, 5nvi, 5nw6, 5o17, 5o18, 5o1k, 5o27, 6eye, 6h5z, 6h6c, 6h6i, 6ra6, 7ohd – mNGB (mutant)
6i3t, 6i40 – mNGB + CO
3gln, 1w92, 4o2g, 4o35, 6h6j – mNGB (mutant) + CO
4o4z – mNGB (mutant) + N₂O
5mjc, 5mjd – mNGB + O₂
4b4y – NGB – Symsagittifera roscoffensis

ReferencesReferences

↑ Uzan J, Dewilde S, Burmester T, Hankeln T, Moens L, Hamdane D, Marden MC, Kiger L. Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding. Biophys J. 2004 Aug;87(2):1196-204. PMID:15298922 doi:http://dx.doi.org/10.1529/biophysj.104.042168
↑ Sun F, Mao X, Xie L, Greenberg DA, Jin K. Neuroglobin protein is upregulated in Alzheimer's disease. J Alzheimers Dis. 2013;36(4):659-63. doi: 10.3233/JAD-130323. PMID:23648513 doi:http://dx.doi.org/10.3233/JAD-130323

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Uzan J, Dewilde S, Burmester T, Hankeln T, Moens L, Hamdane D, Marden MC, Kiger L. Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding. Biophys J. 2004 Aug;87(2):1196-204. PMID:15298922 doi:http://dx.doi.org/10.1529/biophysj.104.042168

[2] Sun F, Mao X, Xie L, Greenberg DA, Jin K. Neuroglobin protein is upregulated in Alzheimer's disease. J Alzheimers Dis. 2013;36(4):659-63. doi: 10.3233/JAD-130323. PMID:23648513 doi:http://dx.doi.org/10.3233/JAD-130323

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