8ce2

X-ray structure of the adduct formed upon reaction of a B-DNA double helical dodecamer with dirhodium tetraacetateX-ray structure of the adduct formed upon reaction of a B-DNA double helical dodecamer with dirhodium tetraacetate

Structural highlights 8ce2 is a 2 chain structure with sequence from DNA molecule. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The reaction of the cytotoxic compound dirhodium tetraacetate with a B-DNA double helical dodecamer was studied by X-ray crystallography and mass spectrometry. The structure of the dirhodium/DNA adduct reveals a dimetallic center binding to an adenine via axial coordination. Complementary information has been gained through ESI MS measurements. Comparison between the present data and those previously obtained for cisplatin indicates that the two metallodrugs react with this DNA dodecamer in a significantly different fashion. Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry.,Tito G, Troisi R, Ferraro G, Geri A, Massai L, Messori L, Sica F, Merlino A Dalton Trans. 2023 May 30;52(21):6992-6996. doi: 10.1039/d3dt00320e. PMID:37199244 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 8ce2, resolution 1.24Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image