7zxt

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cryo-EM structure of Connexin 32 W3S mutation hemi channelcryo-EM structure of Connexin 32 W3S mutation hemi channel

Structural highlights

7zxt is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CXB1_HUMAN X-linked Charcot-Marie-Tooth disease type 1;X-linked progressive cerebellar ataxia. The disease is caused by mutations affecting the gene represented in this entry. The gene represented in this entry may act as a disease modifier.

Function

CXB1_HUMAN One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

7zxt, resolution 2.90Å

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OCA