anti-BTLA monoclonal antibody h22B3 in complex with BTLAanti-BTLA monoclonal antibody h22B3 in complex with BTLA

Structural highlights

8f6o is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BTLA_HUMAN Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.[1]

References

  1. Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9. Epub 2003 Jun 8. PMID:12796776 doi:http://dx.doi.org/10.1038/ni944

8f6o, resolution 2.31Å

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OCA