1k78
Pax5(1-149)+Ets-1(331-440)+DNA
OverviewOverview
Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.
DiseaseDisease
Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]
About this StructureAbout this Structure
1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502 Page seeded by OCA on Fri May 2 22:23:33 2008