1j0s
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Solution structure of the human interleukin-18
OverviewOverview
Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma-, (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity, and developmental regulation of T-lymphocyte helper type I. We determined, the solution structure of IL-18 as a first step toward understanding its, receptor activation mechanism. It folds into a beta-trefoil structure that, resembles that of IL-1. Extensive mutagenesis revealed the presence of, three sites that are important for receptor activation: two serve as, binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions, similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the, third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding., The structure and mutagenesis data provide a basis for understanding the, IL-18-induced heterodimerization of receptor subunits, which is necessary, for receptor activation.
About this StructureAbout this Structure
1J0S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The structure and binding mode of interleukin-18., Kato Z, Jee J, Shikano H, Mishima M, Ohki I, Ohnishi H, Li A, Hashimoto K, Matsukuma E, Omoya K, Yamamoto Y, Yoneda T, Hara T, Kondo N, Shirakawa M, Nat Struct Biol. 2003 Nov;10(11):966-71. Epub 2003 Oct 5. PMID:14528293
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