8ajr

The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2

Structural highlights

8ajr is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A8C5LDB3_JACJA Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).[PIRNR:PIRNR038006]

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8ajr

The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2

Structural highlights

Function

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8ajr

The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2

Structural highlights

Function

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