7wiw

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Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformationCryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation

Structural highlights

7wiw is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IRTB_MYCTU Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).[UniProtKB:G7CBF6][1] [2]

References

  1. ↑ Rodriguez GM, Smith I. Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis. J Bacteriol. 2006 Jan;188(2):424-30. doi: 10.1128/JB.188.2.424-430.2006. PMID:16385031 doi:http://dx.doi.org/10.1128/JB.188.2.424-430.2006
  2. ↑ Ryndak MB, Wang S, Smith I, Rodriguez GM. The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain. J Bacteriol. 2010 Feb;192(3):861-9. doi: 10.1128/JB.00223-09. Epub 2009 Nov 30. PMID:19948799 doi:http://dx.doi.org/10.1128/JB.00223-09

7wiw, resolution 3.12Å

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