Mitogen-activated protein kinase cascade

MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis. RAF kinase B-Raf is related to retroviral oncogenes and participates in cellular signal transduction. B-Raf domains include the kinase domain - residues 444-721 and Ras-binding domain - residues 153-237. Mutated B-Raf was found in some human cancers. See more in B-RAF with PLX4032. c-Raf is part of the MAPK pathway. c-Raf domains include the kinase domain - residues 323-618, cysteine-rich domain – residues 136-187 and Ras-binding domain - residues 51-132. Mutations of c-Raf are possible causes of Noonan syndrome. For details on c-Raf see Molecular Playground/C-Raf. Mitogen-activated protein kinase kinase kinase MAPKs Mitogen-activated protein kinase kinase Mitogen-activated protein kinase Michael Roberts/BIOL115/ERK2 p38 MAPK (UMass Chem 423 Student Projects 2011-2)

spinqualitylabelsall models Human MAPK1 complex with inhibitor and sulfate (PDB entry 2ojg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image