4noa

Truncated minor pilin PilE from Pseudomonas aeruginosaTruncated minor pilin PilE from Pseudomonas aeruginosa

Structural highlights

4noa is a 1 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PILE_PSEAE Essential component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (PubMed:7854130, PubMed:20338182). May stabilize interactions between the major and a minor pilin subcomplex required for efficient pilus biogenesis (PubMed:26359492).^[1] ^[2] ^[3]

References

↑ Giltner CL, Habash M, Burrows LL. Pseudomonas aeruginosa minor pilins are incorporated into type IV pili. J Mol Biol. 2010 May 7;398(3):444-61. doi: 10.1016/j.jmb.2010.03.028. Epub 2010 , Mar 23. PMID:20338182 doi:http://dx.doi.org/10.1016/j.jmb.2010.03.028
↑ Nguyen Y, Harvey H, Sugiman-Marangos S, Bell SD, Buensuceso RN, Junop MS, Burrows LL. Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE. J Biol Chem. 2015 Oct 30;290(44):26856-65. doi: 10.1074/jbc.M115.683334. Epub , 2015 Sep 10. PMID:26359492 doi:http://dx.doi.org/10.1074/jbc.M115.683334
↑ Russell MA, Darzins A. The pilE gene product of Pseudomonas aeruginosa, required for pilus biogenesis, shares amino acid sequence identity with the N-termini of type 4 prepilin proteins. Mol Microbiol. 1994 Sep;13(6):973-85. doi: 10.1111/j.1365-2958.1994.tb00489.x. PMID:7854130 doi:http://dx.doi.org/10.1111/j.1365-2958.1994.tb00489.x

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OCA

[1] Giltner CL, Habash M, Burrows LL. Pseudomonas aeruginosa minor pilins are incorporated into type IV pili. J Mol Biol. 2010 May 7;398(3):444-61. doi: 10.1016/j.jmb.2010.03.028. Epub 2010 , Mar 23. PMID:20338182 doi:http://dx.doi.org/10.1016/j.jmb.2010.03.028

[2] Nguyen Y, Harvey H, Sugiman-Marangos S, Bell SD, Buensuceso RN, Junop MS, Burrows LL. Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE. J Biol Chem. 2015 Oct 30;290(44):26856-65. doi: 10.1074/jbc.M115.683334. Epub , 2015 Sep 10. PMID:26359492 doi:http://dx.doi.org/10.1074/jbc.M115.683334

[3] Russell MA, Darzins A. The pilE gene product of Pseudomonas aeruginosa, required for pilus biogenesis, shares amino acid sequence identity with the N-termini of type 4 prepilin proteins. Mol Microbiol. 1994 Sep;13(6):973-85. doi: 10.1111/j.1365-2958.1994.tb00489.x. PMID:7854130 doi:http://dx.doi.org/10.1111/j.1365-2958.1994.tb00489.x

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