1i4f
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CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX
OverviewOverview
The heterotrimeric complex of the human major histocompatibity complex, (MHC) molecule HLA-A*0201, beta2-microglobulin and the decameric peptide, GVYDGREHTV derived from the melanoma antigen (MAGE-A4 protein has been, determined by X-ray crystallography at 1.4 A resolution. MAGE-A4 belongs, to a family of genes that are specifically expressed in a variety of, tumours. MAGE-A4-derived peptides are presented by MHC molecules at the, cell surface to cytotoxic T-lymphocytes. As the HLA-A*0201:MAGE-A4 complex, occurs only on tumour cells, it is considered to be an appropriate target, for immunotherapy. The structure presented here reveals potential epitopes, specific to the complex and indicates which peptide residues could be, recognised by T-cell receptors. In addition, as the structure could be, refined anisotropically, it was possible to describe the movements of the, bound peptide in more detail.
DiseaseDisease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this StructureAbout this Structure
1I4F is a Protein complex structure of sequences from Homo sapiens with 1PG as ligand. Full crystallographic information is available from OCA.
ReferenceReference
High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene., Hillig RC, Coulie PG, Stroobant V, Saenger W, Ziegler A, Hulsmeyer M, J Mol Biol. 2001 Jul 27;310(5):1167-76. PMID:11502003
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