7vsl

Crystal structure of PDE8A catalytic domain in complex with 10Crystal structure of PDE8A catalytic domain in complex with 10

Structural highlights

7vsl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE8A_HUMAN Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.^[1]

References

↑ Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity. Biochemistry. 2008 Nov 5. PMID:18983167 doi:10.1021/bi801487x

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OCA

[1] Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity. Biochemistry. 2008 Nov 5. PMID:18983167 doi:10.1021/bi801487x

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