Proteopedia

7sk2

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Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformationHuman wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation

Structural highlights

7sk2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[SC6A1_HUMAN] Myoclonic-astatic epilepsy. The disease is caused by variants affecting the gene represented in this entry.

Function

[SC6A1_HUMAN] Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

7sk2, resolution 3.82Å

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OCA
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