7vaf

Cryo-EM structure of Rat NTCP complexed with YN69202FabCryo-EM structure of Rat NTCP complexed with YN69202Fab

Structural highlights

7vaf is a 3 chain structure with sequence from Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NTCP_RAT] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate.[UniProtKB:Q14973]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA