7u9g

Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122

Structural highlights

7u9g is a 9 chain structure with sequence from Homo sapiens and Rabies virus strain Pasteur vaccin. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GLYCO_RABVP] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).

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OCA