1gh6
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RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
OverviewOverview
Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus, 40 (SV40) large T antigen is one of the central features of tumorigenesis, induced by SV40. Both the N-terminal J domain and the LxCxE motif of large, T antigen are required for inactivation of Rb. The crystal structure of, the N-terminal region (residues 7-117) of SV40 large T antigen bound to, the pocket domain of Rb reveals that large T antigen contains a four-helix, bundle, and residues from helices alpha2 and alpha4 and from a loop, containing the LxCxE motif participate in the interactions with Rb. The, two central helices and a connecting loop in large T antigen have, structural similarities with the J domains of the molecular chaperones, DnaJ and HDJ-1, suggesting that large T antigen may use a chaperone, mechanism for its biological function. However, there are significant, differences between large T antigen and the molecular chaperones in other, regions and these differences are likely to provide the specificity needed, for large T antigen to inactivate Rb.
DiseaseDisease
Known diseases associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]
About this StructureAbout this Structure
1GH6 is a Protein complex structure of sequences from Homo sapiens and Simian virus 40. The following page contains interesting information on the relation of 1GH6 with [Simian Virus 40]. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen., Kim HY, Ahn BY, Cho Y, EMBO J. 2001 Jan 15;20(1-2):295-304. PMID:11226179
Page seeded by OCA on Mon Nov 12 17:05:16 2007