4c1q

Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.

Structural highlights 4c1q is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: , , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PRDM9_MOUSE] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase. See Also Histone methyltransferase 3D structures

spinqualitylabelsall models 4c1q, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image