CAD protein

Function

CAD protein is a trifunctional enzyme which contains dihydroorotase domain (DHO), aspartate transcarbamoylase domain (ATC) and carbamoylphosphate synthetase domain^[1]. The CAD protein catalyzes the first 3 of 6 reactions required for pyrimidine biosynthesis.

Disease

Deficiency in carbamoylphosphate synthetase leads to lack of urea and hyperammonemia^[2]

Relevance

Structural highlights

3D structures of CAD protein

CAD protein 3D structures

CAD protein dihydroorotatase subunit complex with dihydroorotate, carbamoyl aspartate, format and Zn+2 ions (PDB ID 4c6d)

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ReferencesReferences

↑ Moreno-Morcillo M, Grande-Garcia A, Ruiz-Ramos A, Del Cano-Ochoa F, Boskovic J, Ramon-Maiques S. Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis. Structure. 2017 Jun 6;25(6):912-923.e5. doi: 10.1016/j.str.2017.04.012. Epub 2017, May 25. PMID:28552578 doi:http://dx.doi.org/10.1016/j.str.2017.04.012
↑ Ng BG, Wolfe LA, Ichikawa M, Markello T, He M, Tifft CJ, Gahl WA, Freeze HH. Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors. Hum Mol Genet. 2015 Jun 1;24(11):3050-7. doi: 10.1093/hmg/ddv057. Epub 2015 Feb, 12. PMID:25678555 doi:http://dx.doi.org/10.1093/hmg/ddv057

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Moreno-Morcillo M, Grande-Garcia A, Ruiz-Ramos A, Del Cano-Ochoa F, Boskovic J, Ramon-Maiques S. Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis. Structure. 2017 Jun 6;25(6):912-923.e5. doi: 10.1016/j.str.2017.04.012. Epub 2017, May 25. PMID:28552578 doi:http://dx.doi.org/10.1016/j.str.2017.04.012

[2] Ng BG, Wolfe LA, Ichikawa M, Markello T, He M, Tifft CJ, Gahl WA, Freeze HH. Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors. Hum Mol Genet. 2015 Jun 1;24(11):3050-7. doi: 10.1093/hmg/ddv057. Epub 2015 Feb, 12. PMID:25678555 doi:http://dx.doi.org/10.1093/hmg/ddv057

[1]

[2]

CAD protein

Contents

Function

Disease

Relevance

Structural highlights

3D structures of CAD protein

ReferencesReferences

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CAD protein

Function

Disease

Relevance

Structural highlights

3D structures of CAD protein

ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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